• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    The invention relates to a cannula arrangement for applying a flow cannula for introducing, passing or diverting flow media, in particular blood, in the human or animal body, the flow cannula (10) having a main section (11) and a tip section (12), characterized in that the tip section (12) is designed to be elastic and arcuately projecting at an angle from the main section (11), and that the tip section (12) is held in the application position by a guide device (14) in the direction of the longitudinal extent of the main section (11) , Furthermore, the invention relates to applications of the cannula assembly.
    公开号:AT516899A1
    申请号:T50944/2015
    申请日:2015-11-06
    公开日:2016-09-15
    发明作者:
    申请人:Klepetko Walter；
    IPC主号:
    专利说明:

    description
    The invention relates to a cannula arrangement for applying a flow cannula for introducing, passing or diverting flow media, in particular blood in the human or animal body, wherein the flow cannula has a main portion and a tip portion.
    Furthermore, the invention relates to a method for setting cannulas and for extracorporeal support of patients with pulmonary hypertension.
    Cannula assemblies and catheter systems have long been known in a variety of forms. So it is already known to lay cannulas from an incision in the groin over the inferior vena cava to the right atrium of the heart. It is also known to puncture the septum of the heart via such a catheter assembly with a puncture wire and the forward end of the catheter, thus laying the cannula to the left atrium of the heart. Transseptal cannulation of the left atrium proves necessary or beneficial for the temporary treatment of severe pulmonary hypertension, as well as for use in conventional ECMO cases (extracorporeal membrane oxygenation) with severe satiety problems.
    Severe pulmonary hypertension in the terminal stage can only be treated by transplantation of the lungs. However, the waiting time for a suitable donation organ can be bridged in extreme cases only by a mechanical relief of the pulmonary circulation. The currently established method represents a peripheral venoarterial ECMO, but represents a significant risk to the patient.
    With the present cannula arrangement and its application, it is possible by interventional transseptal cannulation of the left atrium and in addition the pulmonary artery to create a bypass circuit for the PH flow path (PH = pulmonary hypertension), thereby making it possible for the patient over a longer 1
    Time to stabilize. In the aforementioned clinical picture, the procedure may comprise the following steps: transseptal cannulation of the left atrium (arterial return), transtricuspid cannulation of the pulmonary artery (venus drainage) or normal venous cannulation, connection of the cannulas with a conventional Novalung® (in transtricuspid cannulation ) or with ILA-active (for venous cannulation) or with comparable devices.
    Whenever cannulas need to puncture tissue sections, as is necessary, for example, in the septum for cannulation of the left atrium, there is the problem that the cannula puncture puncture wire necessary for puncture with the puncture tip as possible at a 90-degree angle to the tissue section to judge. This is less of a problem in the septum of the heart when the cannulation is femoral, that is, over the lower major vein, since then the cannula guided into the left atrium and the puncture wire guided into it approach the septum approximately at 90 ° , In the currently known cannula arrangements, it is not possible to provide the preferred access from the upper half of the body. The access from above, for example via the superior vena cava, cervical or subclavicular, is much more comfortable for the patient. The access has a better durability and less susceptibility to problems. Furthermore, the cannula assembly should have anchoring in the septum to prevent dislocation. The final achieved flow rate must be sufficiently large. Moreover, it is desirable to provide the cannula and also the other parts of the cannula assembly with antithrombotic properties. Preferably, the arrangement should also offer the possibility of defect closure in the atrial septum if removed. Finally, the cannula assembly is also intended to enable the connection to the Novalung® system in a manner that is durable and stable, allows easy and rapid change of Novalung®, and minimizes the impact on the patient in physical activities. 9
    According to the invention, the general task of cannulation with approximately 90 ° -igem puncturing a tissue section and in particular the setting of a cannula through the septum of the heart is achieved in that the tip portion is formed elastically and in functional position arcuate at an angle from the main portion projecting, and that the Tip section is held in application system by a guide device in the direction of the longitudinal extent of the main portion.
    Further features of the invention include the following:
    The guide device preferably has a guide wire, a first dilatation cannula which can be pushed over the guide wire, a second dilatation cannula which can be pushed over the first dilatation cannula and a guide sleeve arranged above the second dilatation cannula.
    Another preferred feature is that the first and second dilation cannulae are formed in their tip portions elastically arcuately projecting from the respective major portions at an angle in the same manner as the tip portion of the cannula, the first dilating cannula penetrating through the guide wire and the second dilating cannula guided in her first dilatation and guided along the longitudinal extent of the guide wire.
    Further, it is advantageous if the guide sleeve is removable from the tip portion during application so that it can take the arcuate curvature and the guide sleeve is completely removable and replaceable by the cannula, whereafter the guide wire and the first and second dilation cannulas are removable from the cannula are such that the entire inner cross section of the cannula is released.
    Furthermore, the invention may be characterized in that the tip section of the second dilation cannula adjacent to the tip has a dilatation balloon whose diameter in the inflated state corresponds to the outer diameter of the balloon
    Cannula corresponds and whose diameter in the relaxed state is equal to or smaller than the inner diameter of the cannula.
    The cannula may have a cannula fixing locking device, preferably a balloon, in the tip section.
    The first and second dilation cannula and the cannula is preferably bent in the tip section in the unsupported state by an angle of 20 ° to 100 °, preferably 60 ° to 95 °, particularly preferably 90 °.
    Preferably, the arrangement for transseptal cannulation of the left atrium of the heart is formed with cervical access to the transatrial puncture.
    The surfaces of the parts of the arrangement are preferably equipped antithrombotically, in particular heparinized.
    The invention also relates to the use of the arrangement for transseptal cannulation of the left atrium of the human heart with cervical access, and further to a method for cannulation and extracorporeal support to patients with pulmonary hypertension, or other forms of respiratory failure as defined in the claims ,
    The invention will be explained in more detail with reference to the drawings, for example.
    Fig. 1 shows schematically a cannula assembly according to the prior art.
    Figures 2 to 7 show schematically stepwise the construction and application of the inventive arrangement in the human heart for placement of the flow cannula into the left atrium of the heart.
    Fig. 8 shows another schematic cardiac diagram for explaining the path of an additional pulmonary catheter, and Fig. 9 shows the arrangement of a device for extracorporeal membrane oxidation. 4
    Figure 1 shows the state of the art, as disclosed, for example, by US 8 343 029 B2. A catheter 28 is preferably pushed through an incision in the groin through the inferior vena cava 7 upwards into the right atrium 3 of the heart 1 and penetrates the septum 28 with its tip section so that the catheter terminates in the left atrium 2. However, this position of the catheter and the cannula inserted therewith, which penetrates the body from the groin area to the heart, has the disadvantages described above.
    Fig. 1 shows as prior art also an inserted loop 29, which can be guided by the vein in the region of the collarbone on the upper vena cava 8 down to pull a guide wire, which is provided in the catheter 9 upwards , However, it is not possible to apply a cannula with a corresponding volume and a diameter of about 5 to 9 mm into the left atrial chamber.
    The process according to the invention using the cannula arrangement according to the invention will be explained with reference to FIGS. 2 to 7.
    As a first step, the guide wire 15 is brought with its puncture tip through the septum 28 into the left atrium 2 in a known manner by means of the catheter 9. Then, after removal of the catheter 9, the guide wire is pulled upwards with the loop 29 into the jugular vein or the collarbone vein, the end of the guide wire being guided out of the body through an opening of the vein.
    In Fig. 2 it is shown how the guide wire 15 is guided from the upper vena cava 8 to the left atrium 2. This guidewire - the word "wire" being no limitation on the material - can be very soft and supple.
    If the guidewire 15 turns out to be too soft to adequately guide the first dilation cannula 16, the guidewire may be replaced with a stiffer guidewire by pushing a soft tube, also called a sheet, over the soft wire into the septum The soft one
    Removed wire and the stiff wire is inserted as a new guide wire 24 to the left atrium.
    A stiff wire can also be retracted later, if the following dilatation needles are already set.
    According to FIG. 3, as the next step, the first dilation cannula 16 is inserted over the guidewire 15 or 24 and the first dilatation cannula 16 has a tip section 19 which is pre-bent with sufficient tension (but only so strong that it can still be stretched by the guidewire ), so that the first dilation cannula comes to rest at approximately 90 ° to the septum 28 and can be pushed through the septum 28. This creates a first relatively soft and narrow access from above to the left atrial chamber of the heart.
    According to FIG. 4, a second dilatation cannula 17 is pushed over and along the first dilation cannula 16 in the next step. Also, the second dilation cannula 17 is pre-bent in the tip portion 20 with sufficient bias by about 90 ° relative to the main portion 26. With the aid of the guide sleeve 18 arranged on the outside, however, the tip section 20 of the second dilatation cannula is held straight so that the cannula 16 can just be advanced over the entire main section of the first dilatation cannula 16. The first dilatation cannula contributes to the stiffening of the second dilatation cannula. As soon as the second dilatation cannula comes to the position according to FIG. 4, the guide sleeve 18 is prevented by the physician from accompanying the advancing movement of the second dilatation cannula, so that the tip section leaves the guide sleeve 18 and assumes the bent position corresponding to the pre-bend, as in FIG. 5 is shown. The unsupported position of the cannulas according to FIG. 5 is referred to herein as a functional position, whereas the supported, stretched position of the respective tip sections is referred to as the application layer.
    As also shown in FIG. 5, the second dilation cannula 17 is also pushed into the left atrium 2 through the septum 28, wherein in the tip section of the second dilatation cannula a dilatation balloon 21 is preferably provided which can be inflated in a known manner expand the hole in the septum 28 for the final cannula to be inserted.
    As a next step, the guide sleeve 18 is withdrawn from the dilatation needles to the outside and it is the ultimately required cannula 10 is inserted, which may also have a pre-bent tip portion, during the application during insertion over the two previously introduced dilatation needles the necessary stiffness is given, so the pre-bend is overcome and the cannula 10 can be inserted in a straight shape. Once the bend of Fig. 6 is achieved, the cannula 10 can easily follow the bend and be inserted through the septum into the left atrium.
    To lock the cannula, a locking balloon is shown, which is balloon-shaped as a locking device 27. The locking can also be done by other means, such as. Verspreitzungen.
    As can also be seen in FIG. 6, the dilatation balloon 21 of the second dilation cannula 17 can be expanded by discharging the air pressure so that the outer diameter in the balloon region corresponds approximately to the inner diameter of the cannula 10. Thus, the cannula 10 is released the way through the septum. In the inflated state according to FIG. 5, the balloon 21 has an outer diameter which corresponds to the outer diameter of the cannula 10 and thus expands the hole in the septum such that the cannula 10 can be easily inserted.
    Finally, FIG. 7 shows the finished position of the cannula 10, from which all internal parts, namely guide wire 15 or 24 and both dilatation cannulas 16, 17, have been pulled out. Thus, the full cross-sectional volume of the flow cannula 10 is available as a left atrial cannula (LA cannula) to produce the desired flow rates and flow conditions.
    The number of dilatation cannulas to be pushed over one another is not limited to two. If the dilatation balloon 21 is to be avoided, a third or fourth cannula with the above-mentioned properties can also be coated in order to achieve the necessary expansion of the hole in the septum and the required flow cross section in the last-used flow cannula 10. The dilatation cannulas preferably have an inner free cross-section which allows the cannula to be pushed over the inner guidewire or via the inner dilatation cannula.
    8 is a schematic representation of the arrangement of a further flow cannula as a pulmonary cannula 35 for cannulation of the pulmonary artery 33. In this case, a conventional pulmonary catheter is used via the superior vena cava 8, which is relatively soft and carries a balloon. Such a pulmonary artery catheter may be equipped with a guidewire such that the guidewire is flushed with the catheter through the natural bloodstream via the right atrium 3, through the tricuspid valve 31 into the right ventricle, and from there through the pulmonary valve 32 into the pulmonary artery 33. Preferably, the guidewire is to be inserted into the right pulmonary artery 34.
    Once the guidewire has assumed its desired position, successively one or more cannulas can be successively inserted in the manner described so far, being taken over by the guide wire, the guide and the needles by appropriate flexibility can join the bend in the desired shape.
    With the aid of the first flow cannula 10 (LA cannula) introduced into the left atrium in accordance with FIGS. 2 and 7 and the pulmonary cannula 35 introduced into the pulmonary artery as shown in FIG. 8, it is possible to derive blood from the pulmonary artery into the left atrium Hose connections outside the body, a portable device can be connected, in which removed from the blood C02 and 02 is supplied. This is shown in FIG. 9.
    In FIG. 8, the flow cannula 10 (LA cannula) leading to the left atrial chamber is indicated only in the upper section. The complete position is shown in FIGS. 2 to 7.
    Alternatively, instead of taking blood from the pulmonary artery, a venous blood sample may be taken, for example from the superior vena cava. Using a ß
    Pump assistance (especially a centrifugal pump), the venous blood can be returned via the Novalung or a similar device and the LA cannula in the left atrium of the heart. This alternative is preferred for those cases where pulmonary hypertension is not overly severe and pulmonary function is to be replaced or assisted.
    The procedure and further embodiments are described below:
    Pulmonary hypertension in the terminal stage leads to right ventricular failure. When drug therapy is exhausted, this failure can only be prevented by mechanical circulatory support. All previous methods are either surgically installable, or only suitable for short-term use with no possibility for patient mobility.
    The percutaneous introduction of cannulas via an access from the upper half of the body according to the invention makes it possible to produce a permanent access. In conjunction with a membrane that removes C02 and supplies 02 (e.g., Novalung, ILA = Interventional Lungassist), blood can be redirected from the pulmonary artery to the left atrium. This makes it possible to achieve a reduction in pressure in the pulmonary artery and at the same time to maintain the oxygen saturation of the arterial blood. The blood flow is purely passive, driven by the high pressure efficiency between the pulmonary artery and left atrium, or if this is not sufficient, by an additional pump drive, such as by centrifugal pump.
    By means of the corresponding design of the cannulas in accordance with the invention in conjunction with a carrier bag construction, limited mobility of the patients can be achieved.
    To realize this concept requires: a suitable cannula for draining the blood from the pulmonary artery, namely the pulmonary artery cannula 35,
    Q - a suitable Konnektionsmöglichkeit this cannula with a connector 30, as he is known - a Novalung membrane 36 (with or without pumping assistance) or a similar device, - a suitable Konnektionsmöglichkeit 30 Novalung with the - cannula for returning the blood in the left atrium, namely the LA cannula 10.
    Furthermore, the carrying bag construction 37 is provided.
    The pulmonary cannula is inserted by percutaneous puncture of the subclavian vein, preferably the left subclavian vein. The following steps are necessary: - Puncture of the vein on the Cision 38 - Insertion of a first soft guidewire - On top of this, inserting a catheter with a balloon at the tip. This is similar to a conventional pulmonary catheter but suitable for guiding a stiffer guidewire to be inserted therein. This catheter is passively floated through the blood flow by inflating the balloon through the upper glenoid vein, tricuspid valve 31, pulmonary valve 32 into the pulmonary artery. Thereafter, a second rigid guidewire is advanced within the balloon catheter into the pulmonary artery and the balloon catheter is removed. - Now, the actual Pulmonaliskanüle is placed over the pulmonary artery lying in the guide wire, and positioned there. Thereafter, the guide wire is removed. If necessary, a guide cannula with an extended cross-section can be used as an intermediate step.
    The pulmonary cannula 35 has at its proximal end a connecting device 30, which allows a rapid, simple and stepless connection with the Novalung. This is done by a suitable first Konnektionskanüle 39, so that the necessary configuration is achieved to allow a direct and unhindered access to Novalung. 1 n
    The Novalung used corresponds to the conventionally used membrane devices. This can be mounted in a suitable carrying device 37 in front of the patient's chest so that, although restricted, it is mobile; see FIG. 9. The necessary oxygen supply takes place through an oxygen hose 41 from a separate oxygen reservoir (not shown).
    In the case of using an ILA active with a pumping system, it is possible to mount the entire device on a carrying console. Accordingly, the connectors are to be configured in another suitable configuration, which is familiar to any medical technician.
    Similarly, a second connective cannula 40 is required to provide the necessary connection between the novalization 36 and the left atrial cannula (LA cannula 10).
    The left atrial cannula is introduced according to FIGS. 2 to 7, which is then guided above the upper vena cava 8 into the heart up to the left atrium.
    This arrangement can be used for temporary use, for example, as a bridge to transplantation, or an overall improvement in general recovery of the patient, possibly even after surgery. It can also serve as a permanent support to patients who have no hope for improvement and are not candidates for a transplant. 1 1
    1. Heart 2. Left atrium 3. Right atrium 4. Left ventricle 5. Right ventricle 6. Heart valves 7. Lower vena cava 8. Upper vena cava 9. Catheter 10. Flow cannula (LA cannula) 11. Main section cannula 12. Tip section Cannula 13. Angle 14. Guide device 15. Guide wire soft 16. First dilatation cannula 17. Second dilatation cannula 18. Guide sleeve 19. Tip section of first dilatation cannula 20. Tip section Second dilation cannula 21. Dilatation balloon 22. Diameter Dilatation balloon inflated 23. Diameter Dilatation balloon relaxed 24. Guidewire stiff 25. Main section First dilation cannula 26. Main section Second dilatation cannula 27. Locking device 28. Septum 29. Loop 30. Connector 31. Tricuspid valve 1 9 32. Pulmonary valve 33. Pulmonary artery 34. Right pulmonary artery 35. Pulmonary cannula 36. Novalung membrane 37. Carrying frame 38. Cision 39 Connecting cannula 40. Connecting cannula 41. Oxygen sluice 1 o.
    权利要求:
    Claims (14)
    [1]
    claims
    1. A cannula assembly for applying a flow cannula for on, by or diverting flow media, in particular blood, in the human or animal body, wherein the flow cannula (10) has a main portion (11) and a tip portion (12), characterized in that the tip portion (12) elastically and in the functional position arcuately formed at an angle from the main portion (11) projecting, and that the tip portion (12) is held in the application position by a guide device (14) in the direction of the longitudinal extent of the main portion (11).
    [2]
    2. Arrangement according to claim 1, characterized in that the guide device (4) - a guide wire (15, 24, 30), - a sliding over the guide wire first dilatation cannula (16), - on the first dilatation cannula (10) slidable second Dilatation cannula (17) and optionally further dilation cannulas and - a guide sleeve (18) arranged above the second or outermost dilatation cannula.
    [3]
    3. Arrangement according to claim 2, characterized in that the first and second and optionally each further dilatation cannula (16, 17) in their tip portions (19, 20) in the same manner as the tip portion (12) of the flow cannula (10) elastically arcuate of The first dilatation cannula (16) through the guide wire (15, 24) and the second dilatation cannula (17) and optionally each further by the first dilation cannula disposed therein (16) guided and guided along the longitudinal extent of the guide wire (24).
    [4]
    4. Arrangement according to one of claims 1 to 3, characterized in that the guide sleeve (18) in the application of the tip portion (12) is removable 1Λ, so that it can take the arcuate curvature, and that the guide sleeve (18) completely removable and being replaceable by the flow cannula (10), after which the guidewire (24) and the first and second and any further dilation cannulas (16, 17) on the flow cannula (10) are removable such that the entire interior cross section of the flow cannula (10) is released ,
    [5]
    5. Arrangement according to one of claims 2 to 4, characterized in that the tip portion (20) of the second or outermost dilation cannula (17) adjacent to the tip of a dilatation balloon (21), the diameter (22) in the inflated state, the outer diameter of the cannula and its diameter (23) in the relaxed state is less than or equal to the inner diameter of the cannula.
    [6]
    6. Arrangement according to one of claims 1 to 5, characterized in that the flow cannula (10) in the tip section (12) has a cannula (10) fixing the locking device (27), preferably a balloon having.
    [7]
    7. Arrangement according to one of claims 1 to 6, characterized in that the first, second and possibly following dilatation cannulas (16, 17) and the flow cannula (10) in the tip portion (12) in unsupported state at an angle of 20 ° to 100 °, preferably 60 ° to 95 °, more preferably 90 °, is bent.
    [8]
    8. Arrangement according to one of claims 1 to 7, characterized in that it is designed for transseptal cannulation of the left atrium (2) of the Flerzens (1) with access via the upper flea vein to the transatrial puncture.
    [9]
    9. Arrangement according to one of claims 1 to 8, characterized in that the surfaces of the parts of the arrangement equipped antithrombotic, in particular heparinisert, are. 1 ^
    [10]
    10. Application of the arrangement according to one of claims 1 to 9 for the transseptal cannulation of the left atrium of the human heart with cervical access.
    [11]
    11. Method for setting a cannula for introducing, passing or diverting flow media, in particular blood, into the human or animal body, in particular in the indication pulmonary hypertension, characterized in that - a cannula arrangement with a flow cannula is provided, which comprises a main portion and a tip portion, wherein the tip portion is formed elastically and arcuately projecting at an angle from the main portion, and the tip portion is held in an application position by a guide device in the direction of the longitudinal extent of the main portion, that a catheter having an inside guided guide wire is provided - that an incision on the jugular or subclavian vein introduces a loop to the femoral vein (femoral vein), - that in the groin at the femoral vein the catheter with the guide wire is guided to the right ventricle and the F the guidewire is pulled up to the jugular vein or the collarbone vein, and then the cannula arrangement is placed over the guidewire from the jugular vein or the collateral vein; and that After placing the flow cannula, remove the inner dilatation cannulas and the guidewire.
    [12]
    12. A method for extracorporeal support of patients with pulmonary hypertension, wherein - according to claim 11, a flow cannula as a left atrial cannula for passing blood into the left atrial chamber of the heart, 1 ß - a flow cannula as pulmonary cannula for the discharge of blood from the pulmonary artery, - a Novalung membrane or similar device with the associated oxygen supply, possibly with pumping assistance and the connecting cannulas are provided.
    [13]
    13. The method according to claim 12, characterized in that the left atrial cannula are led out of the body by incision from the right subclavian vein and the Pulmonaliskanüle from the left subclavian vein by incision and connected via the connecting cannulae with the Novalung membrane.
    [14]
    14. A method for extracorporeal support of patients with pulmonary insufficiency, wherein - according to claim 11, a flow cannula as left atrial cannula for passing blood into the left atrial chamber of the heart and - a cannula for venous blood sampling, for example, placed in the superior vena cava - and the cannulas with the Novalung or similar device and optionally an extracorporeal pump, preferably centrifugal pump, connected to replace or support the lung function. 1 7
    类似技术:
    公开号 | 公开日 | 专利标题
    EP2395944B1|2020-09-23|Cathetersystem for reconstruction of an anatomic structure
    DE102007043831B4|2009-07-02|catheter
    DE69626822T2|2004-03-04|ENDOVASCULAR SYSTEM FOR GENERATING A HEART STOP
    DE60116786T2|2006-08-31|MINIMAL INVASIVE SYSTEM WITH TEMPLATE FOR AN ANLULOPLASTIC REPAIR SEGMENT
    DE69736610T2|2007-09-20|COLLABORABLE EXHAUST CATHETER
    DE60017125T2|2005-12-08|TRANSPLANT CATHETER FOR VASCULAR ACCESS SYSTEM
    DE60307599T2|2007-08-09|MULTILUMEN CATHETER FOR MINIMIZING LINERIES
    DE69938002T2|2009-01-15|DEVICE FOR INTRAVASCULARLY MOUNTING A CANNULA AND APPLICATION METHOD
    DE60308293T2|2007-04-05|Blood treatment catheter device
    DE69916244T2|2005-05-25|BREATHER FOR BENDED CANNULA
    DE69731979T2|2005-12-01|DIALYSIS CATHETER WITH RIGID AND COLLABORABLE LUMINA
    DE69829468T2|2006-02-09|VASCULAR ACCESSORY SYSTEM FOR HEMODIALYSIS
    DE19546692C2|2002-11-07|Self-expanding heart valve prosthesis for implantation in the human body via a catheter system
    DE60109737T2|2006-02-23|HIGH PERFORMANCE NEEDLES
    DE102005042338B4|2007-07-05|catheter device
    DE10217559A1|2003-11-13|Device for minimally invasive, intravascular aortic valve extraction
    EP0996472A1|2000-05-03|Intracardiac blood pump
    DE19933522A1|2000-09-14|Cardiac assistance device, to increase blood supply to heart; has reinforcement piece contacting area of heart tissue to limit expansion of heart
    CH684307A5|1994-08-31|Extension of linear and tubular tissue.
    DE10261575A1|2004-07-08|Device for cannulating a blood-carrying vessel and its use for cannulating blood-carrying vessels
    WO2016034171A2|2016-03-10|Catheter
    EP1894593B1|2011-04-20|Device for introducing a cannula into a blood vessel
    EP1584304A1|2005-10-12|A conduit for introducing into a blood vessel
    EP1725293B1|2008-07-30|Balloon catheter
    DE102016104429A1|2016-09-15|The cannula assembly
    同族专利:
    公开号 | 公开日
    US10357637B2|2019-07-23|
    US20190344052A1|2019-11-14|
    AT516898A1|2016-09-15|
    US20160263302A1|2016-09-15|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    US5314418A|1990-09-21|1994-05-24|Toyo Boseki Kabushiki Kaisha|Cannula|
    WO1992006733A1|1990-10-19|1992-04-30|Trustees Of Boston University|Percutaneous transseptal left atrial cannulation system|
    EP2233169A1|2009-03-27|2010-09-29|CircuLite, Inc.|Transseptal cannula device, coaxial balloon delivery device, and methods of using the same|
    US20110160517A1|2009-12-31|2011-06-30|Cardiacassist, Inc.|System for heart assist, cannula and method|
    US8343029B2|2007-10-24|2013-01-01|Circulite, Inc.|Transseptal cannula, tip, delivery system, and method|
    JP6586172B2|2014-10-31|2019-10-02|セレバスク，エルエルシーＣｅｒｅＶａｓｃ，ＬＬＣ|Method and system for treating hydrocephalus|US20200316351A1|2019-04-04|2020-10-08|Medtronic, Inc.|Cannula delivery catheter and procedure method|
    法律状态:
    2018-07-15| REJ| Rejection|Effective date: 20180715 |
    优先权:
    申请号 | 申请日 | 专利标题
    ATA50197/2015A|AT516898A1|2015-03-11|2015-03-11|The cannula assembly|US14/942,198| US10357637B2|2015-03-11|2015-11-16|Cannula assembly for fitting a flow cannula for introducing, circulating or diverting flow media, and method for extracorporeal support of a patient with pulmonary hypertension or pulmonary insufficiency|
    DE102016104429.6A| DE102016104429A1|2015-03-11|2016-03-10|The cannula assembly|
    EP16159901.4A| EP3067000A1|2015-03-11|2016-03-11|Cannula assembly|
    US16/420,741| US20190344052A1|2015-03-11|2019-05-23|Cannula assembly for fitting a flow cannula for introducing, circulating or diverting flow media, and method for extracorporeal support of a patient with pulmonary hypertension or pulmonary insufficiency|
    [返回顶部]